Two Fractions of Melanocyte Stimulating Hormone in Urine.

Y2-Melanocyte-Stimulating Hormone

Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance

OBJECTIVE Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood. Desacetyl-α-MSH is considered to be unimportant for regulating energy b...

-Melanocyte-Stimulating Hormone Inhibits Allergic Airway Inflammation

Plasma ACTH and melanocyte-stimulating hormone in nail pigmentation.

occur with some anticancer agents such as cyclophosphamide (Shah et al., 1975), 5-FU and nitrogen mustard (Moore and Meiselbaugh, 1975), and also with exposure to x-rays (Sutton, 1952; Inalshingh, 1972). Priestman and James (1975) reported 3 cases in which nail changes were possibly due to doxorubicin. They speculated that this drug has a selective hormone-suppressive action which might allow a...

Enzymatic Arginylation of @=Melanocyte-stimulating Hormone and of Angiotensin II*

Porcine /3-melanocyte-stimulating hormone and angiotensin II were examixied as acceptors in the reaction catalyzed by arginyl-tRNA-protein transferase. Both inhibited enzymatic transfer of [l%]arginine from tRNA to bovine albumin. Inhibition was competitive with albumin and the Ki values were, respectively, 15 and 0.8 PM. The expected arginylated compounds were isolated and characterized. &Mela...